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KMID : 0615720110280030043
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Jouranl of Korean Acupuncture and Moxibustion society
2011 Volume.28 No. 3 p.43 ~ p.54
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Anti-inflammatory Effect on Desmodii Herba Pharmacopuncture at KI10 on Nephritis in Rats
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Yoon Kwang-Shik
Kang Jae-Hui
Lee Hyun
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Abstract
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Objectives:This study was designed to evaluate the effects of Desmodii herb pharmacopuncture (DH-HA) at KI10(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rat.
Methods: Rats were injected LPS to induce nephritis. DH-HA group was treated with DH-HA at KI10 three times for a week, NP group with 26 gauge needle, saline group with normal saline. To evaluate the effects of DH-HA at KI10 on nephritis in rats, RBC, WBC, neutrophil in blood, TNF-a, CINC-1 in serum, creatinine and total protein in urine, renal TNF-a, renal MPO were measured and renal tissue was analyzed.
Results: WBC in blood, CINC-1 in serum, renal MPO significantly reduced in DH-HA group.
Conclusions: DH-HA at KI10 is effective for nephritis in LPS-induced rats. Therefore, DH-HA at KI10 may be useful for nephritis in clinical field.
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KEYWORD
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nephritis, pharmacopuncture, KI10, Desmodii herb
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